Angiogenic Self-Assembling Peptide Scaffolds for Functional Tissue Regeneration,Biomacromolecules

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Angiogenic Self-Assembling Peptide Scaffolds for Functional Tissue Regeneration
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-08-22 00:00:00 , DOI: 10.1021/acs.biomac.8b01137
Biplab Sarkar , Peter K. Nguyen , William Gao , Akhil Dondapati , Zain Siddiqui , Vivek A. Kumar ₁

Affiliation

Implantation of acellular biomimetic scaffolds with proangiogenic motifs may have exciting clinical utility for the treatment of ischemic pathologies such as myocardial infarction. Although direct delivery of angiogenic proteins is a possible treatment option, smaller synthetic peptide-based nanostructured alternatives are being investigated due to favorable factors, such as sustained efficacy and high-density epitope presentation of functional moieties. These peptides may be implanted in vivo at the site of ischemia, bypassing the first-pass metabolism and enabling long-term retention and sustained efficacy. Mimics of angiogenic proteins show tremendous potential for clinical use. We discuss possible approaches to integrate the functionality of such angiogenic peptide mimics into self-assembled peptide scaffolds for application in functional tissue regeneration.

中文翻译：

用于功能组织再生的血管生成自组装肽支架。

具有促血管生成基序的脱细胞仿生支架的植入可能具有令人兴奋的临床效用，可用于治疗缺血性疾病，例如心肌梗塞。尽管直接递送血管生成蛋白是一种可能的治疗选择，但是由于有利的因素，例如持续的功效和功能性部分的高密度表位呈递，正在研究较小的基于合成肽的纳米结构替代物。这些肽可以绕过首过代谢而在缺血部位植入体内，从而能够长期保留并保持持续的功效。血管生成蛋白的模拟物显示出巨大的临床应用潜力。

更新日期：2018-08-22

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