Förster Resonance Energy Transfer‐Activated Processes in Smart Nanotheranostics Fabricated in a Sustainable Manner,ChemSusChem

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Förster Resonance Energy Transfer‐Activated Processes in Smart Nanotheranostics Fabricated in a Sustainable Manner
ChemSusChem ( IF 7.5 ) Pub Date : 2018-09-19 , DOI: 10.1002/cssc.201801441
Dominika Wawrzyńczyk ₁ , Urszula Bazylińska ₂ , Łukasz Lamch ₂ , Julita Kulbacka ₃ , Anna Szewczyk ₃ , Artur Bednarkiewicz ₄ , Kazimiera A. Wilk ₂ , Marek Samoć ₁

Affiliation

Multilayer nanocarriers loaded with optically activated payloads are gaining increasing attention due to their anticipated crucial role for providing new mechanisms of energy transfers in the health‐oriented applications, as well as for energy storage and environmental protection. The combination of careful selection of optical components for efficient Förster resonance energy transfer, and surface engineering of the nanocarriers, allowed us to synthesize and characterize novel theranostic nanosystems for diagnosis and therapy of deep‐seated tumors. The cargo, constrained within the oil core of the nanocapsules, composed of NaYF₄:Tm⁺³, Yb⁺³ up‐converting nanoparticles together with a second‐generation porphyrin‐based photosensitizing agent—Verteporfin, assured requisite diagnostic and therapeutic functions under near‐IR laser excitation. The outer polyaminoacid shell of the nanocapsules was functionalized with a ligand—poly(l‐glutamic acid) functionalized by PEG‐ylated folic acid—to ensure both a “stealth” effect and active targeting towards human breast cancer cells. The preparation criteria of all nanocarrier building blocks meet the requirements for sustainable and green chemistry practices. The multifunctionality of the proposed nanocarriers is a consequence of both the surface‐functionalized organic exterior part, which was accessible for selective accumulation in cancer cells, and the hydrophobic optically active interior, which shows phototoxicity upon irradiation within the first biological window.

中文翻译：

以可持续方式制造的智能纳米热力学中的Förster共振能量转移激活过程

装载有光活化有效载荷的多层纳米载体，由于其预期的关键作用，即在面向健康的应用中提供新的能量转移机制，以及在能量存储和环境保护中发挥着至关重要的作用，因此受到越来越多的关注。精心选择光学组件以实现有效的Förster共振能量转移以及纳米载体的表面工程的结合，使我们能够合成和表征用于诊断和治疗深部肿瘤的新型治疗学纳米系统。货物被限制在纳米胶囊的油核中，由NaYF ₄：Tm ⁺³，Yb ^+3组成上转换纳米粒子与第二代基于卟啉的光敏剂Verteporfin一起，可确保在近红外激光激发下具有必要的诊断和治疗功能。纳米胶囊的聚氨基酸外层壳通过配体-聚（l谷氨酸）被PEG化叶酸功能化，以确保“隐形”效果和对人乳腺癌细胞的主动靶向作用。所有纳米载体构建基块的制备标准均符合可持续和绿色化学实践的要求。所提议的纳米载体的多功能性是表面功能化的有机外部部分（可在癌细胞中选择性积聚）和疏水性光学活性内部的结果，疏水性光学活性内部在第一个生物窗口中受到照射后显示出光毒性。

更新日期：2018-09-19

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