Synthesis and Biomedical Applications of Multifunctional Nanoparticles,Advanced Materials

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Synthesis and Biomedical Applications of Multifunctional Nanoparticles
Advanced Materials ( IF 27.4 ) Pub Date : 2018-08-21 , DOI: 10.1002/adma.201802309
Dokyoon Kim ₁ , Kwangsoo Shin ₁ , Soon Gu Kwon ₁ , Taeghwan Hyeon _{1,

2}

Affiliation

The accumulated knowledge of nanoparticle (NP) synthesis for the last 30 years has enabled the development of functional NPs for biomedical applications. Especially, NPs with multifunctional capabilities are gaining popularity as the demand for versatile and efficient NP agents increases. Various combinations of functional materials are integrated to form multicomponent NPs with designed size, structure, and multifunctionality. Their use as diagnostic and/or therapeutic tools is demonstrated, suggesting their application potentials in healthcare and medical practice. Here, the recent achievements in the synthesis and biomedical applications of multifunctional NPs are summarized. Starting with a brief overview regarding the advances in NP synthesis and accompanying progress in nanobiotechnology, various components to construct the multifunctional NP agents, which include polymers and mesoporous, magnetic, catalytic, and semiconducting NPs, are discussed together with their overall integration forms, such as NP assembly, hollow/porous structures, or hybrid/doped systems. Following the explanation of the features that multifunctional NP agents can offer, an outlook and a brief comment regarding the future research directions are provided.

中文翻译：

多功能纳米粒子的合成及生物医学应用

过去30年中积累的纳米颗粒（NP）合成知识使生物医学应用功能性NP的开发成为可能。尤其是，随着对多功能和高效NP代理的需求增加，具有多功能功能的NP越来越受欢迎。功能材料的各种组合被集成以形成具有设计尺寸，结构和多功能性的多组分NP。证明了它们作为诊断和/或治疗工具的用途，表明它们在保健和医学实践中的应用潜力。在此，总结了多功能NP的合成和生物医学应用方面的最新成就。首先简要介绍NP合成的进展以及纳米生物技术的伴随进展，讨论了构建多功能NP试剂的各种成分，包括聚合物和介孔，磁性，催化和半导体NP，以及它们的整体整合形式，例如NP组装，中空/多孔结构或混合/掺杂系统。在对多功能NP代理可以提供的功能进行了解释之后，提供了有关未来研究方向的展望和简短评论。

更新日期：2018-08-21

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