Abstract Bismuth-based medicines, which are generally available without prescription, are used for a variety of purposes including stomach relief, diarrhea, and cold sores. The determination of Bi in these types of medicines using MIP OES is considered easy, due to the relatively high concentrations of this element. However, high dilution factors can lead to systematic errors and thus low precision. Furthermore, the drugs, excipients, and other active pharmaceutical ingredients (APIs) present in these products can cause spectral and matrix interferences. The present study evaluates the use of multiple spectral lines as a strategy to avoid analytical difficulties. For comparative purposes, hydride generation and standard additions techniques were also evaluated. The results demonstrated the feasibility of using the sum of the intensities of multiple lines to improve accuracy, minimizing systematic errors from spectral interferences and matrix effects, employing simple calculations in a data spreadsheet. The accuracies, calculated based on labeled values, varied from 89.2 to 98.8% and from 72.2 to 124% for direct analysis without and with standard additions, respectively, from 73.2 to 114% for hydride generation, and from 89.8 to 101% for the multiple lines sum method.

中文翻译：

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在 MIP OES 测量中使用多条线来提高精度，最大限度地减少光谱干扰引起的系统误差，并减少基质效应

摘要 铋基药物通常无需处方即可获得，可用于多种用途，包括缓解胃痛、腹泻和唇疱疹。使用 MIP OES 测定这些类型药物中的 Bi 被认为很容易，因为该元素的浓度相对较高。然而，高稀释因子会导致系统误差，从而导致精度低。此外，这些产品中存在的药物、赋形剂和其他活性药物成分 (API) 会导致光谱和基质干扰。本研究评估使用多谱线作为避免分析困难的策略。出于比较的目的，还评估了氢化物生成和标准添加技术。结果表明，在数据电子表格中采用简单的计算，使用多条线的强度总和来提高精度、最大限度地减少光谱干扰和基质效应造成的系统误差是可行的。基于标记值计算的准确度分别为 89.2% 至 98.8% 和 72.2% 至 124%（不添加和添加标准物的直接分析），氢化物生成的准确度为 73.2% 至 114%，多重分析的准确度为 89.8% 至 101%行总和法。