The 2017 American College of Neuropychopharmacology (ACNP) conference hosted a Study Group on 4 December 2017, Establishing best practice guidelines to improve the rigor, reproducibility, and transparency of the maternal immune activation (MIA) animal model of neurodevelopmental abnormalities. The goals of this session were to (a) evaluate the current literature and establish a consensus on best practices to be implemented in MIA studies, (b) identify remaining research gaps warranting additional data collection and lend to the development of evidence-based best practice design, and (c) inform the MIA research community of these findings. During this session, there was a detailed discussion on the importance of validating immunogen doses and standardizing the general design (e.g., species, immunogenic compound used, housing) of our MIA models both within and across laboratories. The consensus of the study group was that data does not currently exist to support specific evidence-based model selection or methodological recommendations due to lack of consistency in reporting, and that this issue extends to other inflammatory models of neurodevelopmental abnormalities. This launched a call to establish a reporting checklist focusing on validation, implementation, and transparency modeled on the ARRIVE Guidelines and CONSORT (scientific reporting guidelines for animal and clinical research, respectively). Here we provide a summary of the discussions in addition to a suggested checklist of reporting guidelines needed to improve the rigor and reproducibility of this valuable translational model, which can be adapted and applied to other animal models as well.

中文翻译：

---

母体免疫激活：报告指南以提高模型的严谨性、可重复性和透明度。

2017 年美国神经精神药理学会 (ACNP) 会议于 2017 年 12 月 4 日主持了一个研究小组，制定最佳实践指南以提高母体免疫激活 (MIA) 神经发育异常动物模型的严谨性、可重复性和透明度。本次会议的目标是 (a) 评估当前文献并就将在 MIA 研究中实施的最佳实践达成共识，(b) 确定需要额外收集数据的剩余研究差距，并有助于制定循证最佳实践设计，以及 (c) 将这些发现告知 MIA 研究社区。在本次会议期间，详细讨论了验证免疫原剂量和标准化总体设计（例如，物种、使用的免疫原性化合物、住房）我们的 MIA 模型在实验室内和跨实验室。研究小组的共识是，由于报告缺乏一致性，目前不存在支持特定循证模型选择或方法学建议的数据，并且该问题扩展到神经发育异常的其他炎症模型。这发起了建立报告清单的呼吁，该清单以 ARRIVE 指南和 CONSORT（分别为动物和临床研究的科学报告指南）为模型，重点关注验证、实施和透明度。在这里，除了建议的报告指南清单外，我们还提供了讨论摘要，以提高这一有价值的转化模型的严谨性和可重复性，该模型也可以改编并应用于其他动物模型。