A Convenient Synthesis of 1,2‐Disubstituted‐cis‐3,4‐Dihydroxypyrrolidines via an Ugi‐Four‐Component‐Reaction/Cycloisomerization/Dihydroxylation Protocol,European Journal of Organic Chemistry

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A Convenient Synthesis of 1,2‐Disubstituted‐cis‐3,4‐Dihydroxypyrrolidines via an Ugi‐Four‐Component‐Reaction/Cycloisomerization/Dihydroxylation Protocol
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-17 , DOI: 10.1002/ejoc.201800756
Gemma Flores-Constante ₁ , Anahí C. Sánchez-Chávez ₁ , Luis A. Polindara-García ₁

Affiliation

The development of a practical method for the synthesis of 1,2‐disubstituted‐3,4‐dihydroxypyrrolidine analogs based on a cycloisomerization/dihydroxylation sequence from Ugi four‐component‐reaction/propargylamine adducts is described.