Abstract In the present investigation, a novel strategy of continuous microwave assisted flow synthesis (CMFS) has been adopted in comparison to traditional synthesis procedures (sol-gel and chemical precipitation method) for the quick production of TiO2 nanoparticles with very fine particle properties. The X-ray powder diffraction analysis (XRPD) and transmission electron microscopy (TEM) were two techniques used for analysing the properties related to structure and particle morphology of the resultant samples. It was observed that the particles formed by using continuous flow route were less agglomerated, and particle size (~ 6 nm) was smaller in comparison with others obtained using sol-gel (~ 9 nm) and chemical precipitation method (~ 15 nm). X-ray diffraction impressions established the generation of Anatase phase with preferential [101] dimension. Zeta potential computations were taken to inspect the colloidal stability of nanoparticles. Antimicrobial nature of TiO2 nano-samples was analyzed by using various bacterial and fungal strains. The nanostructured TiO2 particles confirmed outstanding uniformity with respect to chemical and structure. This new ceramic substance with strong antimicrobial activity promised magnificent potential in bone tissue engineering.

中文翻译：

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纳米二氧化钛颗粒的新型合成和抗菌研究

摘要 在本研究中，与传统合成方法（溶胶-凝胶法和化学沉淀法）相比，采用了一种新的连续微波辅助流动合成 (CMFS) 策略来快速生产具有非常细颗粒特性的 TiO2 纳米粒子。X 射线粉末衍射分析 (XRPD) 和透射电子显微镜 (TEM) 是用于分析与所得样品的结构和颗粒形态相关的性质的两种技术。观察到，与使用溶胶-凝胶法 (~ 9 nm) 和化学沉淀法 (~ 15 nm) 获得的其他粒子相比，通过使用连续流路形成的颗粒团聚较少，粒径 (~ 6 nm) 更小。X 射线衍射印迹确定了具有优先[101]尺寸的锐钛矿相的生成。Zeta 电位计算被用来检查纳米粒子的胶体稳定性。通过使用各种细菌和真菌菌株分析了 TiO2 纳米样品的抗菌性质。纳米结构的 TiO2 颗粒证实了化学和结构方面的出色均匀性。这种具有强抗菌活性的新型陶瓷物质有望在骨组织工程中发挥巨大的潜力。