Bottom-up synthesis of MoS2 nanospheres for photothermal treatment of tumors,Photochemical & Photobiological Sciences

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Bottom-up synthesis of MoS2 nanospheres for photothermal treatment of tumors
Photochemical & Photobiological Sciences ( IF 2.7 ) Pub Date : 2018-08-16 00:00:00 , DOI: 10.1039/c8pp00198g
Shun Gao _{1,

2,

3} , Hailiang Zhou _{1,

2,

3} , Sumei Cui _{1,

2,

3} , Hai Shen _{1,

2,

3}

Affiliation

Photothermal therapy (PTT) is providing new opportunities for killing cancer cells. In this work, we introduce a new nanomedicine based on spherical MoS₂ nanoparticles for PTT treatment of tumors, prepared using “green” bottom-up technology. To increase water solubility and avoid rapid clearance by the reticuloendothelial system, polyethylene glycol (PEG) was used to coat them. These MoS₂-PEG nanospheres with an appropriate size (∼100 nm) exhibit high photothermal conversion efficiency (26.7%). In vitro cellular studies revealed that the MoS₂-PEG nanospheres showed negligible cytotoxicity. Additionally, through combining the MoS₂-PEG nanosphere samples with NIR irradiation at 808 nm, excellent in vitro tumor cell killing efficacy was achieved. In the 4T1 tumor model, the MoS₂-PEG nanospheres exhibited good antitumor efficiency in vivo, displaying complete tumor inhibition over 16 days after treatment. Therefore, MoS₂-PEG nanospheres played an important role in tumor destruction, and this concept for developing spherical MoS₂-based nanomedicines can serve as a platform technology for the next generation of in vivo PTT agents.

中文翻译：

MoS ₂纳米球的自下而上合成，用于肿瘤的光热治疗

光热疗法（PTT）为杀死癌细胞提供了新的机会。在这项工作中，我们介绍了一种基于球形MoS ₂纳米粒子的新型纳米药物，用于通过PTT治疗肿瘤，采用“绿色”自下而上的技术制备。为了增加水溶性并避免被网状内皮系统快速清除，使用了聚乙二醇（PEG）对其进行包覆。这些具有合适尺寸（约100 nm）的MoS ₂ -PEG纳米球表现出高的光热转化效率（26.7％）。体外细胞研究表明，MoS ₂ -PEG纳米球的细胞毒性可忽略不计。此外，通过将MoS ₂ -PEG纳米球样品与808 nm的NIR辐射结合，达到了体外杀死肿瘤细胞的功效。在4T1肿瘤模型中，MoS ₂ -PEG纳米球在体内表现出良好的抗肿瘤效果，在治疗后的16天中显示出完全的肿瘤抑制作用。因此，MoS ₂ -PEG纳米球在肿瘤破坏中起着重要作用，并且这种用于开发基于球形MoS ₂的纳米药物的概念可以用作下一代体内PTT剂的平台技术。

更新日期：2018-08-16

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