Recent work published by Dong and co-workers in Nature Chemistry addresses the long-standing “ortho-constraint” in Catellani-type reactions by employing a new class of bridgehead-modified norbornenes as the mediator. The previously unsuccessful ortho-unsubstituted aryl iodides are well tolerated in current reaction systems in that they deliver a wide range of mono ortho-C‒H-functionalized products with high efficiency.

中文翻译：

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桥头修饰的NBEs：解决Catellani型反应中邻位约束的方法

Dong和他的同事在《自然化学》杂志上发表的最新著作通过采用新型桥头修饰的降冰片烯作为介体，解决了卡特兰尼型反应中长期存在的“邻位约束”问题。在当前的反应系统中，先前失败的邻位未取代的芳基碘化物是可以很好地耐受的，因为它们可以高效地提供多种单邻位-C‒H-官能化的产物。