Five silver camphor complexes of formulae [Ag₂(L)(L′)₂] (1,3,5) or [Ag(L)₂(L′)] (2,4) were synthesized from silver nitrate and the suitable camphor carboxylate (L¹) or camphor carboxamides (L³, L⁴). The complexes were characterized by elemental analysis and spectroscopic techniques (NMR, FTIR, XPS). Computational calculations support coordination of the carboxylate group to silver, in the case of complex 2 and combined mixed keto/carboxylate in the case of complex 1. The stability of the complexes highly relies on the tetrahedral geometry of the lithium ion that binds to four oxygen atoms of the camphor carboxylate ligands. The redox properties of complexes 1 and 4 studied by cyclic voltammetry confirm the facile reduction of the metal sites that depending on the experimental conditions may lead to formation of silver nanoparticles as confirmed by XPS and TEM. Complexes 1, 2 and 4 were tested for cytotoxic activities against A2780 (IC₅₀, 11–14 μM) and A2780 cisplatin resistant (A2780cisR) (IC₅₀, 4–7 μM) cells using the MTT assay. The result showed that the complexes have anticancer activity higher than cisplatin. Complex 1 was also probed for cytotoxicity against the non-tumoral human embryonic kidney (HEK 293, IC₅₀, 62.2 ± 16 μM) cells showing low toxicity in agreement with the silver camphor carboxylate complexes having a considerable selectivity for the ovarian cancer cells A2780 and cisplatin resistant A2780cisR which is a key point under pharmacological uses.

五式银樟脑络合物将[Ag ₂（L）（L'）₂ ]（1，3，5）或将[Ag（L）₂（L'）]（2，4）从硝酸银和合适的合成樟脑羧酸盐（L ¹）或樟脑羧酰胺（L ³，L ⁴）。通过元素分析和光谱技术（NMR，FTIR，XPS）对复合物进行表征。计算计算支持在配合物2的情况下将羧酸酯基团与银配位，在配合物1的情况下将酮/羧酸酯混合混合。配合物的稳定性高度依赖于与樟脑羧酸盐配体的四个氧原子结合的锂离子的四面体几何形状。通过循环伏安法研究的配合物1和4的氧化还原特性证实了金属位点的轻度还原，这取决于实验条件可能导致形成银纳米粒子，如XPS和TEM所证实。配合物1，2和4为细胞毒活性进行了测试针对A2780（IC ₅₀，11-14μM）和A2780顺铂抗性（A2780cisR）（IC ₅₀，使用MTT分析法检测4–7μM）细胞。结果表明，该复合物具有比顺铂更高的抗癌活性。复杂1还探查对非肿瘤的人胚胎肾细胞毒性（HEK 293，IC ₅₀，62.2±16μM）表示有对卵巢癌细胞A2780相当选择性的银樟脑羧酸络合物协议低毒性的细胞和耐顺铂的A2780cisR是药理学应用中的关键点。