Antimicrobials in indoor dust pose concerns due to their endocrine disrupting activities and potential promotion of antibiotic resistance. We adopted dispersive solid phase extraction (d-SPE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to quantify antimicrobials in dust. The method showed favorable linearity (R² >0.99), recovery (83–115%), and method detection limits (1.2–5.6 ng/g, dry weight). All seven analytes were found at median concentrations in ng/g in each of the 80 U.S. dust samples collected from athletic facilities and residential homes: methyl paraben (1920) > propyl paraben (965) > triclosan (390) > triclocarban (270) > ethyl paraben (195) > butyl paraben (80) > benzyl paraben (6). Triclosan levels in dust from athletic facilities were significantly higher than those in private homes (p < 0.05). Median estimated daily intake (EDI) of antimicrobials in ng/kg-body weight/d from dust ingestion was lowest for adults (1.9) and higher for more sensitive subpopulations, including infants (19.8), toddlers (23.6), children (11.8) and teenagers (4.6). This first application of d-SPE to the analysis of dust produced U.S. baseline data for triclosan and triclocarban levels in indoor dust just prior to the 2017 Federal ban on use of these trichlorinated aromatics in antiseptic soaps and related personal care products.

室内粉尘中的抗菌素由于其内分泌干扰活动和潜在的抗生素耐药性提升而引起关注。我们采用了分散固相萃取（d-SPE）和液相色谱-串联质谱（LC-MS / MS）来量化粉尘中的抗菌剂。该方法显示出良好的线性（R ²> 0.99），回收率（83–115％）和方法检测限（1.2–5.6 ng / g，干重）。在从运动设施和民居收集的80个美国灰尘样品中，所有七个分析物均以ng / g的中位浓度表示：对羟基苯甲酸甲酯（1920）>对羟基苯甲酸丙酯（965）>三氯生（390）>三氯卡班（270）>对羟基苯甲酸乙酯（195）>对羟基苯甲酸丁酯（80）>对羟基苯甲酸苄酯（6）。运动设施灰尘中的三氯生水平显着高于私人住宅中的三氯生水平（p <0.05）。成人摄入灰尘的抗微生物药物的每日估计中位数摄入量（ng / kg体重/ d）最低（1.9），对于较敏感的亚群则更高，包括婴儿（19.8），学步儿童（23.6），儿童（11.8）和青少年（4.6）。d-SPE首次用于粉尘分析时，就在2017年联邦禁令在杀菌肥皂和相关个人护理产品中使用这些三氯化芳烃之前，就产生了美国室内尘埃中三氯生和三氯卡班含量的基线数据。