Investigating the Clough, Lutz, and Jirgensons Rule for the pH Dependence of Optical Rotation of Amino Acids,Journal of Chemical Education

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Investigating the Clough, Lutz, and Jirgensons Rule for the pH Dependence of Optical Rotation of Amino Acids
Journal of Chemical Education ( IF 2.5 ) Pub Date : 2018-08-15 00:00:00 , DOI: 10.1021/acs.jchemed.8b00348
Scott Simpson ₁ , Alexandra M. Izydorczak ₁

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Students in an upper-level physical chemistry course used a polarimeter to measure the molar optical rotation of different optically active amino acids to confirm the Clough, Lutz, and Jirgensons (CLJ) rule. This rule states that an amino acid is in the l-configuration if the molar optical rotation becomes more positive upon the addition of acid or the acid is of the d-configuration if the optical rotation becomes more negative in an acidified solution. Students demonstrated this rule for known configurations of amino acids and then applied this rule to determine the configuration of an amino acid with an unknown configuration.

中文翻译：

研究氨基酸旋光性的pH依赖性的Clough，Lutz和Jirgensons规则

参加高级物理化学课程的学生使用旋光仪测量了不同旋光氨基酸的摩尔旋光度，以确认Clough，Lutz和Jirgensons（CLJ）规则。该规则指出，如果在加入酸时摩尔旋光性变得更正，则氨基酸为l-构型，或者如果在酸化溶液中旋光性变得更负，则酸为d-构型。学生演示了此规则的已知氨基酸构型，然后应用此规则确定具有未知构型的氨基酸的构型。

更新日期：2018-08-15

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