Mild Base Promoted Nucleophilic Substitution of Unactivated sp3‐Carbon Electrophiles with Alkenylboronic Acids,Advanced Synthesis & Catalysis

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Mild Base Promoted Nucleophilic Substitution of Unactivated sp3‐Carbon Electrophiles with Alkenylboronic Acids
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-09-05 , DOI: 10.1002/adsc.201800826
Shiwen Liu ₁ , Xiaojun Zeng ₁ , Gerald B. Hammond ₂ , Bo Xu ₁

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Diverse alkenylboronic acids react smoothly with various sp³‐carbon electrophiles such as unactivated alkyl triflates in the presence of mild bases such as K₃PO₄. The reaction protocol is very mild and thereby enables high functional group tolerance. This transition metal‐free condition is orthogonal towards the classic transition metal catalyzed Suzuki coupling.

中文翻译：

轻度碱促进未活化的sp3-碳亲电试剂与烯基硼酸的亲核取代

在温和的碱（例如K ₃ PO _4）存在下，不同的烯基硼酸与各种sp ^3-碳亲电试剂（例如未活化的烷基三氟甲磺酸酯）平滑反应。反应方案非常温和，因此可以实现较高的官能团耐受性。这种无过渡金属的条件与经典的过渡金属催化的Suzuki偶联正交。

更新日期：2018-09-05

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