当前位置: X-MOL 学术Adv. Synth. Catal. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Mild Base Promoted Nucleophilic Substitution of Unactivated sp3‐Carbon Electrophiles with Alkenylboronic Acids
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-09-05 , DOI: 10.1002/adsc.201800826
Shiwen Liu 1 , Xiaojun Zeng 1 , Gerald B. Hammond 2 , Bo Xu 1
Affiliation  

Diverse alkenylboronic acids react smoothly with various sp3‐carbon electrophiles such as unactivated alkyl triflates in the presence of mild bases such as K3PO4. The reaction protocol is very mild and thereby enables high functional group tolerance. This transition metal‐free condition is orthogonal towards the classic transition metal catalyzed Suzuki coupling.

中文翻译:

轻度碱促进未活化的sp3-碳亲电试剂与烯基硼酸的亲核取代

在温和的碱(例如K 3 PO 4)存在下,不同的烯基硼酸与各种sp 3-碳亲电试剂(例如未活化的烷基三氟甲磺酸酯)平滑反应。反应方案非常温和,因此可以实现较高的官能团耐受性。这种无过渡金属的条件与经典的过渡金属催化的Suzuki偶联正交。
更新日期:2018-09-05
down
wechat
bug