Recent advances in the delivery of hydrogen sulfide via a macromolecular approach,Polymer Chemistry

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Recent advances in the delivery of hydrogen sulfide via a macromolecular approach
Polymer Chemistry ( IF 4.1 ) Pub Date : 2018-08-14 00:00:00 , DOI: 10.1039/c8py00938d
Matthew C. Urquhart _{1,

2,

3,

4,

5} , Francesca Ercole _{1,

2,

3,

4,

5} , Michael R. Whittaker _{1,

2,

3,

4,

5} , Ben J. Boyd _{1,

2,

3,

4,

5} , Thomas P. Davis _{1,

2,

3,

4,

5} , John F. Quinn _{1,

2,

3,

4,

5}

Affiliation

Engineered macromolecules such as polymer conjugates, micelles, hydrogels and nanofibers continue to attract interest as drug delivery systems due to their potential to improve therapeutic outcomes. One area where engineered macromolecules have considerable potential is in the delivery of endogenous signalling molecules, such as hydrogen sulfide (H₂S). Until recently the application and investigation of H₂S was limited to the use of small molecule donors, although the use of macromolecular systems may confer considerable advantages. This mini review provides a brief overview of recent advances in the use of macromolecules as H₂S donors. In particular, we examine the use of materials that release H₂S both spontaneously and in response to chemical or physical triggers. In many of the highlighted examples macromolecules are reported to provide precise, controlled and sustained production of H₂S, demonstrating their potential as advanced platforms for H₂S delivery.

中文翻译：

通过高分子方法输送硫化氢的最新进展

工程化的大分子，例如聚合物结合物，胶束，水凝胶和纳米纤维，由于其改善治疗效果的潜力而继续受到药物输送系统的关注。工程化的大分子具有相当大的潜力的一个领域是内源性信号分子，如硫化氢（H ₂ S）的传递。直到最近，H ₂ S的应用和研究仅限于小分子供体的使用，尽管使用大分子系统可能会带来可观的优势。这篇小型综述简要概述了使用高分子作为H ₂ S供体的最新进展。特别是，我们研究了释放H ₂的材料的使用S可以自发地响应化学或物理触发。在许多突出显示的实例中，据报道，大分子可提供精确，受控和持续的H ₂ S产生，证明了其作为H ₂ S输送的先进平台的潜力。

更新日期：2018-08-14

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