High Cure Rates With Grazoprevir-Elbasvir With or Without Ribavirin Guided by Genotypic Resistance Testing Among Human Immunodeficiency Virus/Hepatitis C Virus–coinfected Men Who Have Sex With Men,Clinical Infectious Diseases

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High Cure Rates With Grazoprevir-Elbasvir With or Without Ribavirin Guided by Genotypic Resistance Testing Among Human Immunodeficiency Virus/Hepatitis C Virus–coinfected Men Who Have Sex With Men
Clinical Infectious Diseases ( IF 8.2 ) Pub Date : 2018-08-13 , DOI: 10.1093/cid/ciy547
Dominique L Braun _{1,

2} , Benjamin Hampel _{1,

2} , Roger Kouyos _{1,

2} , Huyen Nguyen ₁ , Cyril Shah ₂ , Markus Flepp ₃ , Marcel Stöckle ₄ , Anna Conen ₅ , Charles Béguelin ₆ , Patrizia Künzler-Heule ₇ , Dunja Nicca ₇ , Patrick Schmid ₈ , Julie Delaloye ₉ , Mathieu Rougemont ₁₀ , Enos Bernasconi ₁₁ , Andri Rauch ₆ , Huldrych F Günthard _{1,

2} , Jürg Böni ₂ , Jan S Fehr _{1,

12} ,

Affiliation

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Switzerland.
Institute of Medical Virology, University of Zurich.
Center of Infectious Diseases Zurich.
Division of Infectious Diseases & Hospital Epidemiology, University Hospital Basel, University of Basel.
Division of Infectious Diseases and Hospital Hygiene, Cantonal Hospital Aarau.
Department of Infectious Diseases, Bern University Hospital, University of Bern.
Institute of Nursing Science, University Hospital Basel, University of Basel.
Division of Infectious Diseases, Cantonal Hospital St Gallen.
Intensive Care Unit, Department of Intensive Care Medicine, University of Lausanne and University Hospital Center.
Division of Infectious Diseases, University Hospital Geneva.
Division of Infectious Diseases, Regional Hospital Lugano.
Department Public Health, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Switzerland.

This study was performed to investigate the efficacy and safety of grazoprevir-elbasvir guided by baseline resistance-associated substitutions (RASs) in the Swiss HCVree Trial.

中文翻译：

在人类免疫缺陷病毒/丙型肝炎病毒合并感染的男男性行为者中，以基因型耐药性测试为指导，使用或不使用利巴韦林的 Grazoprevir-Elbasvir 的高治愈率

本研究旨在调查在瑞士 HCVree 试验中以基线耐药相关替代 (RAS) 为指导的 grazoprevir-elbasvir 的疗效和安全性。

更新日期：2018-08-13

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