PURPOSE To investigate the associations between intraocular pressure (IOP) measurements obtained by different tonometric methods and rates of visual field loss in a cohort of patients with glaucoma followed over time. DESIGN Prospective, observational cohort study. PARTICIPANTS This study included 213 eyes of 125 glaucomatous patients who were followed for an average of 2.4±0.6 years. METHODS At each visit, IOP measurements were obtained using Goldmann applanation tonometry (GAT), the Ocular Response Analyzer (ORA) (Reichert, Inc., Depew, NY), corneal-compensated IOP (IOPcc), and the ICare Rebound Tonometer (RBT) (Tiolat, Oy, Helsinki, Finland). Rates of visual field loss were assessed by standard automated perimetry (SAP) mean deviation (MD). Linear mixed models were used to investigate the relationship between mean IOP by each tonometer and rates of visual field loss over time, while adjusting for age, race, central corneal thickness, and corneal hysteresis. MAIN OUTCOME MEASURES Strength of associations (R2) between IOP measurements from each tonometer and rates of SAP MD change over time. RESULTS Average values for mean IOP over time measured by GAT, ORA, and RBT were 14.4±3.3, 15.2±4.2, and 13.4±4.2 mmHg, respectively. Mean IOPcc had the strongest relationship with SAP MD loss over time (R2 = 24.5%) and was significantly different from the models using mean GAT IOP (R2 = 11.1%; 95% confidence interval [CI] of the difference, 6.6-19.6) and mean RBT IOP (R2= 5.8%; 95% CI of the difference, 11.1-25.0). CONCLUSIONS Mean ORA IOPcc was more predictive of rates of visual field loss than mean IOP obtained by GAT or RBT. By correcting for corneal-induced artifacts, IOPcc measurements may present significant advantages for predicting clinically relevant outcomes in patients with glaucoma.

中文翻译：

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视野进展速度与不同眼压计获得的眼压测量值之间的关联。

目的探讨随着时间的推移，通过不同的眼压测量方法获得的眼内压（IOP）测量值与一群青光眼患者的视野丧失率之间的关系。设计前瞻性，观察性队列研究。参与者本研究纳入了125例青光眼患者的213眼，平均随访时间为2.4±0.6年。方法每次访视时，均使用戈德曼压平眼压计（GAT），眼反应分析仪（ORA）（Reichert，Inc.，Depew，NY），角膜补偿眼压（IOPcc）和ICare回弹眼压计（RBT）获得IOP测量值）（蒂奥拉特，奥伊，赫尔辛基，芬兰）。通过标准自动视野检查（SAP）平均偏差（MD）评估视野丧失率。使用线性混合模型调查每个眼压计的平均IOP与随时间变化的视野丧失率之间的关系，同时调整年龄，种族，中央角膜厚度和角膜滞后。主要观察指标每个眼压计的IOP测量值与SAP MD速率随时间的变化之间的关联强度（R2）。结果通过GAT，ORA和RBT测得的随时间推移的平均IOP平均值分别为14.4±3.3、15.2±4.2和13.4±4.2 mmHg。随着时间的推移，平均IOPcc与SAP MD损失之间的关系最密切（R2 = 24.5％），并且与使用平均GAT IOP的模型存在显着差异（R2 = 11.1％； 95％的置信区间[CI]，差异为6.6-19.6）以及平均RBT IOP（R2 = 5.8％；差异的95％CI，11.1-25.0）。结论平均ORA IOPcc比通过GAT或RBT获得的平均IOP更能预测视野丢失率。通过矫正角膜引起的伪影，IOPcc测量可为预测青光眼患者的临床相关结局提供显着优势。