Dreissenid mussels, well-known invaders of the northern hemisphere, also constitute good biomonitors for freshwater quality assessment. Whereas the oldest, Dreissena polymorpha, is relatively well-known, the new invasive, Dreissena rostriformis bugensis, has been very little characterized. The aim of this study was to compare subcellular biomarker responses within these species, by taking into account inter- and intra-specific variability in biomarker responses during a multi-stress assessment. Indeed, due to local environmental conditions and genetic background, biomarker responses can be different between populations of a given species, not only between species. To evaluate these differential responses, we sampled mussels on two sites where they are both present in sympatry (plus another D. r. bugensis population), and we exposed these populations in laboratory to different stressors: thermal stress (12 or 17 °C), dietary stress (fed or unfed), contamination (nickel at 0, 20 and 500 μg L⁻¹) and exposure duration (0, 4 or 8 days). Results mainly evidenced strong inter-species and inter-population differences, underlining the need to discriminate correctly between the two species and to know well the populations used in biomonitoring. Results also evidenced thermal and food stress-related effects. The numerous data obtained during this multi-stress experiment also highlight the complexity of working on several stressors and analysing the associated results.

北半球著名的入侵者Dreissenid贻贝，也构成了用于评估淡水水质的良好生物监测器。最古老的多形果蝇（Dreissena polymorpha）是相对著名的，而新的侵入性多孢果蝇（Dreissena rostriformis bugensis），几乎没有特征。这项研究的目的是通过在多压力评估过程中考虑生物标记物应答的种间和种内变异性，比较这些物种中的亚细胞生物标记物应答。实际上，由于当地环境条件和遗传背景，给定物种的种群之间，不仅只是物种之间的生物标志物响应可能是不同的。为了评估这些差异响应，我们在两个都存在共生体的地点（以及另外的D. r。bugensis种群）采样了贻贝，并将这些种群在实验室中暴露于不同的压力源：热胁迫（12或17°C） ，饮食压力（喂食或不喂食），污染（镍含量为0、20和500μgL ^-1时））和暴露时间（0、4或8天）。结果主要证明物种间和种群间存在巨大差异，强调需要正确区分两种物种并充分了解生物监测所用种群。结果还证明了热量和食物压力相关的影响。在此多压力实验期间获得的大量数据还凸显了在多个压力源上进行工作以及分析相关结果的复杂性。