Copper‐Catalyzed Defluorinative Thioannulation of Trifluoropropynes for the Synthesis of 1,2‐Dithiole‐3‐thiones,Advanced Synthesis & Catalysis

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Copper‐Catalyzed Defluorinative Thioannulation of Trifluoropropynes for the Synthesis of 1,2‐Dithiole‐3‐thiones
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-09-04 , DOI: 10.1002/adsc.201800846
Feng Wei ₁ , Xiao-Qin Shen ₁ , Xiao-Hong Zhang ₁ , Xing-Guo Zhang ₁

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A simple and practical strategy for the preparation of 1,2‐dithiole‐3‐thiones via copper‐catalyzed defluorinative thioannulation of trifluoropropynes has been developed using elemental sulfur as the sole sulfur source. This reaction displays a wide substrate scope and high functional group tolerance to afford the corresponding S‐heterocycles in moderate to good yields and features efficient construction of multiple C−S bonds through C−F bond cleavage of CF₃ groups.

中文翻译：

铜催化的三氟丙炔脱氟硫代环化反应合成1,2-二硫代3-硫酮

通过元素硫作为唯一的硫源，开发了一种简单实用的方法，该方法通过铜催化的三氟丙炔的脱氟硫代环化反应制备1,2-二硫代3-硫酮。该反应显示出较宽的底物范围和较高的官能团耐受性，能够以中等至良好的产率提供相应的S-杂环，并具有通过CF ₃基团的CF键断裂有效构建多个CS键的特征。

更新日期：2018-09-04

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