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Carbene capture in a myoglobin mutant
Nature Catalysis ( IF 42.8 ) Pub Date : 2018-08-10 , DOI: 10.1038/s41929-018-0129-y
Emily H. Edwards , Kara L. Bren

Carbene capture in a myoglobin mutant

Carbene capture in a myoglobin mutant, Published online: 10 August 2018; doi:10.1038/s41929-018-0129-y

Metalloprotein activity can be tuned by altering first- and second-sphere interactions with the metal ion or ions. Here, a non-canonical haem axial ligand is introduced into a myoglobin variant, modulating both. The resulting enhancement of cyclopropanation activity illustrates the utility of expanding the suite of available amino acids for biocatalyst engineering.


中文翻译:

肌红蛋白突变体中的碳捕获

肌红蛋白突变体中的碳捕获

肌红蛋白突变体中的碳捕获,在线发布:2018年8月10日; doi:10.1038 / s41929-018-0129-y

金属蛋白活性可以通过改变与一个或多个金属离子的第一和第二球相互作用来调节。在此,将非规范的血红素轴向配体引入到肌红蛋白变体中,对两者进行调节。所产生的环丙烷化活性的增强说明了扩展用于生物催化剂工程的可用氨基酸套件的实用性。
更新日期:2018-08-11
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