Microbial accumulation in materials used in sectors such as medical, textile and food can lead to serious diseases, infections and uncontrollable problems. Many of the materials used in the above-mentioned industries have highly sensitive surfaces for microorganisms and cause colonization and biofilm formation. Colonization and biofilm formation threaten human health and they cause many diseases that result in death every year. Antimicrobial materials have an important role in combating pathogens. This article is about a new material with antibiofilm and antimicrobial properties combining polyurethane and Hypericum perforatum extract (PHPE) together. Antimicrobial effect of H. perforatum extract was determined against three clinical pathogens; C. albicans, E. coli and S. aureus. The highest antimicrobial activity of H. perforatum extract was found against S. aureus strain. Antibiofilm analysis results revealed that H. perforatum was also inhibited by the biofilm formation of S. aureus by 56.85%. The combination of polyurethane material and H. perforatum extract (PHPE) resulted in 92.85% decrease in S. aureus biofilm compared to control group. The reduction of S. aureus after H. perforatum incorporation was revealed by Scanning Electron Microscopy (SEM) study. The results show that the polyurethane material combined with H. perforatum extract inhibits the formation of S. aureus biofilm.

微生物在医疗，纺织和食品等行业所用材料中的积累会导致严重的疾病，感染和无法控制的问题。在上述工业中使用的许多材料具有对微生物高度敏感的表面，并引起定植和生物膜形成。殖民化和生物膜的形成威胁着人类的健康，每年都会导致许多疾病并导致死亡。抗菌材料在抵抗病原体方面具有重要作用。本文介绍了一种具有抗生物膜和抗菌特性的新型材料，该材料将聚氨酯和贯叶连翘提取物（PHPE）结合在一起。测定了贯叶连翘提取物对三种临床病原体的抗菌作用。白色念珠菌，大肠杆菌和金黄色葡萄球菌。发现贯叶连翘提取物对金黄色葡萄球菌菌株具有最高的抗菌活性。抗生物膜分析结果表明，穿孔菌也被金黄色葡萄球菌的生物膜形成抑制了56.85％。与对照组相比，聚氨酯材料和贯叶连翘提取物（PHPE）的组合导致金黄色葡萄球菌生物膜减少92.85％。通过扫描电子显微镜（SEM）研究揭示了贯叶连翘的掺入后金黄色葡萄球菌的减少。结果表明，聚氨酯材料与贯叶连翘提取物抑制金黄色葡萄球菌生物膜的形成。