Organization of Amino Acids into Layered Supramolecular Secondary Structures,Accounts of Chemical Research

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Organization of Amino Acids into Layered Supramolecular Secondary Structures
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2018-08-10 00:00:00 , DOI: 10.1021/acs.accounts.8b00131
Santu Bera ₁ , Sudipta Mondal ₁ , Sigal Rencus-Lazar ₁ , Ehud Gazit ₁

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The unique physiochemical properties and multiscale organization of layered materials draw the attention of researchers across a wide range of scientific disciplines. Layered structures are commonly found in diverse biological systems where they fulfill various functions. A prominent example of layered biological materials is the organization of proteins and polypeptides into the archetypal aggregated amyloidal structures. While the organization of proteins into amyloid structures was initially associated with various degenerative disorders, it was later revealed that proteins not related to any disease could also form identical layered assemblies. Thus, it appears that the ability of peptides and proteins to produce amyloid-like aggregates represents a generic property of polyamides to assemble into higher order fibrillar structures. In the aggregated state, the peptide backbone forms β-sheet structures which are further organized into layered arrangements.

中文翻译：

氨基酸组织成层状的超分子二级结构

层状材料的独特理化性质和多尺度组织吸引了众多科学领域的研究人员的注意力。分层结构通常出现在履行各种功能的各种生物系统中。分层生物材料的一个突出例子是蛋白质和多肽组织到原型聚集的淀粉样蛋白结构中。虽然蛋白质组织成淀粉样蛋白结构最初与各种退行性疾病有关，但后来发现与任何疾病无关的蛋白质也可以形成相同的分层组装体。因此，看来肽和蛋白质产生淀粉样样聚集体的能力代表了聚酰胺组装成较高级原纤维结构的一般性质。

更新日期：2018-08-10

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