Visible Light‐Mediated Trifluoromethylation of Fluorinated Alkenes via C−F Bond Cleavage,Advanced Synthesis & Catalysis

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Visible Light‐Mediated Trifluoromethylation of Fluorinated Alkenes via C−F Bond Cleavage
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-09-04 , DOI: 10.1002/adsc.201800740
Liu-Hai Wu ₁ , Jun-Kee Cheng ₁ , Liang Shen ₁ , Zhi-Liang Shen ₂ , Teck-Peng Loh _{1,

2}

Affiliation

A convenient photoredox‐catalyzed defluorinative trifluoromethylation of α‐trifluoromethyl alkenes and gem‐difluoroalkenes is developed. The reactions proceeded efficiently via trifluoromethyl radical addition followed by β‐fluorine elimination process, providing a new entry to multifluorinated alkenes in moderate to good yields with excellent stereoselectivity.

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