Pre-/post-functionalization in dipyrrin metal complexes – antitumor and antibacterial activity of their glycosylated derivatives†,Dalton Transactions

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Pre-/post-functionalization in dipyrrin metal complexes – antitumor and antibacterial activity of their glycosylated derivatives†
Dalton Transactions ( IF 3.5 ) Pub Date : 2018-08-08 00:00:00 , DOI: 10.1039/c8dt03059f
Claudia S. Gutsche _{1,

1,

2,

3,

4} , Susanna Gräfe _{4,

5,

6} , Burkhard Gitter _{4,

5,

6} , Keith J. Flanagan _{7,

8,

9,

10,

11} , Mathias O. Senge _{7,

8,

9,

10,

11} , Nora Kulak _{1,

2,

3,

4} , Arno Wiehe _{1,

2,

3,

4,

5}

Affiliation

A post-functionalization route to tris(dipyrrinato) metal complexes is presented giving access to a range of new complexes relevant in the context of medicinal inorganic chemistry. A pentafluorophenyl group in the meso-position of the dipyrrin ligand serves as an anchor for the connection with alcohols and thiocarbohydrates. The photochemotherapeutic activity of the complexes has been assessed in cellular assays with tumor cell lines and against the Gram-positive bacterium S. aureus. Finally, it is shown that this post-functionalization is also applicable to other dipyrrinato metal complexes.

中文翻译：

双吡啶金属配合物的前/后功能化-其糖基化衍生物的抗肿瘤和抗菌活性†

提出了一种向三（dipyrrinato）金属配合物的后功能化途径，使人们可以使用与药用无机化学有关的一系列新配合物。在二吡啶配体的中间位置上的五氟苯基用作与醇和硫代碳水化合物连接的锚。在具有肿瘤细胞系和针对革兰氏阳性细菌金黄色葡萄球菌的细胞试验中已经评估了复合物的光化学治疗活性。最后，表明该后官能化也适用于其他二吡咯烷酮金属络合物。

更新日期：2018-08-08

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