Hydrogen/deuterium exchange coupled with high-resolution mass spectrometry was successfully applied for the identification of A-type tetrameric, pentameric, and hexameric procyanidins in peanut skin. This extended a previous study on isomeric cyclic B-type unconventional tetramer, pentamer, and hexamer procyanidins found in wine and cranberries. Not only had the method successfully identified the procyanidins with a single A-linkage (e.g., tetrameric m/z 1153.2608) by means of distinguishing them from their isomeric cyclic B-type analogues, but this method also worked for procyanidins with two or more A-linkages (such as the tetrameric m/z 1151.2452). As a further consequence, B-type cyclic pentamers and hexamers in wine have been elucidated with hydrogen/deuterium exchange (HDX) for the first time.

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氢/氘交换结合高分辨率质谱法已成功用于花生皮中A型四聚体，五聚体和六聚体原花青素的鉴定。这扩展了先前对葡萄酒和蔓越莓中发现的异构环状B型非常规四聚体，五聚体和六聚体原花青素的研究。该方法不仅通过将它们与同分异构的环状B型类似物区别开来，成功地鉴定了具有单个A键的原花青素（例如，四聚体m / z 1153.2608），而且该方法还适用于具有两个或更多个A的原花青素。 -链接（例如四聚体m / z1151.2452）。进一步的结果是，葡萄酒中的B型环状五聚体和六聚体首次通过氢/氘交换（HDX）得以阐明。

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