Two protected galacto-dendritic units have been axially coordinated to the central ion of a silicon(IV) phthalocyanine to afford SiPcPGal4 containing four units of galactose per macrocycle. These biological moieties provided better solubility in aqueous medium and a sensitizer with higher absorption peaks at 680-690 nm. The photodynamic activity of SiPcPGal4 was evaluated against UM-UC-3 human bladder cancer cell line and the results were compared with the activity of the reported SiPcPGal2 and SiPc(OH)2 . SiPcPGal4 had a better uptake and it was a better toxicity inducer than SiPcPGal2 and SiPc(OH)2 owing to its four galactose units, protected by isopropylidene groups, which can act as targeted micelles.

中文翻译：

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半乳糖树突状硅（IV）酞菁在癌症光动力疗法中作为光敏剂。

两个受保护的半树突状树突单元已轴向与硅（IV）酞菁的中心离子配位，以提供每个大环包含四个单元半乳糖的SiPcPGal4。这些生物部分在水性介质中提供了更好的溶解度，并在680-690 nm处具有更高吸收峰的敏化剂。评估了SiPcPGal4对UM-UC-3人膀胱癌细胞系的光动力活性，并将结果与​​报道的SiPcPGal2和SiPc（OH）2的活性进行了比较。与SiPcPGal2和SiPc（OH）2相比，SiPcPGal4具有更好的吸收性，并且是更好的毒性诱导剂，这是因为它的四个半乳糖单元受异亚丙基保护，可以用作目标胶束。