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Polyamine derivatives from the bee pollen of Quercus mongolica with tyrosinase inhibitory activity
Bioorganic Chemistry ( IF 4.5 ) Pub Date : 2018-08-10 , DOI: 10.1016/j.bioorg.2018.08.014
Seon Beom Kim , Qing Liu , Jong Hoon Ahn , Yang Hee Jo , Ayman Turk , In Pyo Hong , Sang Mi Han , Bang Yeon Hwang , Mi Kyeong Lee

Eighteen constituents, including nine new compounds, were isolated from the bee pollen of Quercus mongolica. The structures of the new compounds were established on the basis of combined spectroscopic analysis. Structurally, the nine new compounds are polyamine derivatives with phenolic moieties which were assigned as one putrescine derivative, mogolicine A (2), seven spermidine derivatives, mongolidines A-G (35, 8, 12, 14, 17) and one spermine derivative, mogoline A (18). Evaluation of the biological activity of isolated compounds revealed that the polyamine derivatives with coumaroyl and caffeoyl moieties showed tyrosinase inhibition with IC50 values of 19.5–85.8 μM; however, the addition of a methoxy group to phenolic derivatives reduced the inhibitory activity.



中文翻译:

蒙古栎蜂花粉中具有酪氨酸酶抑制活性的多胺衍生物

蒙古栎的蜂花粉中分离出18种成分,包括9种新化合物。在组合光谱分析的基础上建立了新化合物的结构。在结构上,九个新化合物是被指定为一个腐胺衍生物与酚部分的聚胺衍生物,mogolicine A(2),七亚精胺衍生物,mongolidines AG(3 - 58121417)和一个精胺衍生物, Mogoline A(18)。对分离出的化合物的生物学活性的评估表明,具有香豆酰基和咖啡酰基部分的多胺衍生物显示出酪氨酸酶抑制作用,IC 50值为19.5–85.8μM。但是,在酚衍生物中加甲氧基会降低其抑制活性。

更新日期:2018-08-10
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