BACKGROUND Clinical sequelae of Ebola virus disease (EVD) have not been described more than 3 years postoutbreak. We examined survivors and close contacts from the 1995 Ebola outbreak in Kikwit, Democratic Republic of Congo (DRC), and determined prevalence of abnormal neurological, cognitive, and psychological findings and their association with EVD survivorship. METHODS From August to September 2017, we conducted a cross-sectional study in Kikwit, DRC. Over 2 decades after the EVD outbreak, we recruited EVD survivors and close contacts from the outbreak to undergo physical examination and culturally adapted versions of the Folstein mini-mental status exam (MMSE) and Goldberg anxiety and depression scale (GADS). We estimated the strength of relationships between EVD survivorship and health outcomes using linear regression models by comparing survivors versus close contacts, adjusting for age, sex, educational level, marital status, and healthcare worker status. RESULTS We enrolled 20 EVD survivors and 187 close contacts. Among the 20 EVD survivors, 4 (20%) reported at least 1 abnormal neurological symptom, and 3 (15%) had an abnormal neurological examination. Among the 187 close contacts, 14 (11%) reported at least 1 abnormal neurologic symptom, and 9 (5%) had an abnormal neurological examination. EVD survivors had lower mean MMSE and higher mean GADS scores as compared to close contacts (MMSE: adjusted coefficient: -1.85; 95% confidence interval [CI]: -3.63, -0.07; GADS: adjusted coefficient: 3.91; 95% CI: 1.76, 6.04). CONCLUSIONS EVD survivors can have lower cognitive scores and more symptoms of depression and anxiety than close contacts more than 2 decades after Ebola virus outbreaks.

中文翻译：

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1995 年刚果民主共和国基奎特埃博拉病毒爆发后埃博拉病毒病幸存者的神经、认知和心理发现：一项横断面研究。

背景 埃博拉病毒病 (EVD) 的临床后遗症在暴发后 3 年以上未见报道。我们检查了 1995 年刚果民主共和国 (DRC) 基奎特埃博拉疫情的幸存者和密切接触者，并确定了异常神经、认知和心理发现的患病率及其与 EVD 存活率的关系。方法 2017 年 8 月至 9 月，我们在刚果民主共和国 Kikwit 进行了一项横断面研究。埃博拉病毒病爆发后的 20 多年，我们招募了埃博拉病毒病幸存者和爆发时的密切接触者，以进行身体检查和 Folstein 小型精神状态检查 (MMSE) 和戈德堡焦虑和抑郁量表 (GADS) 的文化适应版本。我们通过比较幸存者与密切接触者、调整年龄、性别、教育水平、婚姻状况和医护人员状况，使用线性回归模型估计了 EVD 存活率与健康结果之间的关系强度。结果 我们招募了 20 名埃博拉病毒病幸存者和 187 名密切接触者。在 20 名 EVD 幸存者中，4 名 (20%) 报告至少 1 项异常神经系统症状，3 名 (15%) 有异常神经系统检查。187名密切接触者中，14人（11%）报告至少1项异常神经系统症状，9人（5%）有神经系统检查异常。与密切接触者相比，EVD 幸存者的平均 MMSE 和平均 GADS 评分较低（MMSE：调整系数：-1.85；95% 置信区间 [CI]：-3.63，-0.07；GADS：调整系数：3.91；95% CI： 1.76，6.04）。