Hydrogen-bonded supramolecular polymer nanoparticles (SPNPs), serving as a ratiometric oxygen nanoprobe for hypoxia sensing and photodynamic therapy (PDT) treatment, were designed. Herein, oxygen-sensitive phosphorescent Pt(II) porphyrin moiety and oxygen-insensitive fluorescent 9,10-diphenylanthracene moiety were assembled through quadruple hydrogen bonding into SPNPs. The efficient energy transfer between the monomeric donor–acceptor pairs in the SPNPs leads to enhanced phosphorescence with long lifetimes. The resulting bright phosphorescence can realize hypoxia sensing in living cells and generate singlet oxygen efficiently in SPNPs to kill cancer cells. This is the first example of a multi-functional supramolecular polymer-based nanoprobe for ratiometric hypoxia sensing, imaging and PDT treatment.

中文翻译：

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发光的超分子聚合物纳米粒子，用于比例式缺氧检测，成像和治疗†

设计了氢键超分子聚合物纳米粒子（SPNPs），作为用于缺氧传感和光动力疗法（PDT）治疗的比例氧纳米探针。在此，通过四氢键合将氧敏感的磷光Pt（II）卟啉部分和氧敏感的荧光9,10-二苯基蒽部分组装成SPNP。SPNP中单体供体-受体对之间的有效能量转移导致磷光增强，寿命长。产生的明亮的磷光可以在活细胞中实现缺氧感测，并在SPNP中有效产生单线态氧以杀死癌细胞。这是用于比例式缺氧检测，成像和PDT治疗的多功能超分子聚合物纳米探针的第一个示例。