Mucosal barriers constitute major body surfaces that are in constant contact with the external environment. Mucosal sites are densely populated by a myriad of distinct neurons and immune cell types that sense, integrate and respond to multiple environmental cues. In the recent past, neuro-immune interactions have been reported to play central roles in mucosal health and disease, including chronic inflammatory conditions, allergy and infectious diseases. Discrete neuro-immune cell units act as building blocks of this bidirectional multi-tissue cross-talk, ensuring mucosal tissue health and integrity. Herein, we will focus on reciprocal neuro-immune interactions in the airways and intestine. Such neuro-immune cross-talk maximizes sensing and integration of environmental aggressions, which can be considered an important paradigm shift in our current views of mucosal physiology and immune regulation.

中文翻译：

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粘膜生理学的神经免疫调节。

粘膜屏障构成了与外部环境持续接触的主要身体表面。粘膜部位密集分布着无数不同的神经元和免疫细胞类型，它们可以感知、整合并对多种环境线索做出反应。最近，据报道神经免疫相互作用在粘膜健康和疾病中起着核心作用，包括慢性炎症、过敏和传染病。离散的神经免疫细胞单元充当这种双向多组织串扰的基石，确保粘膜组织的健康和完整性。在此，我们将重点关注气道和肠道中的相互神经免疫相互作用。这种神经免疫串扰最大限度地感知和整合了环境侵害，