Tunable aggregation of gold-silica janus nanoparticles to enable contrast-enhanced multiwavelength photoacoustic imaging in vivo†,Nanoscale

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Tunable aggregation of gold-silica janus nanoparticles to enable contrast-enhanced multiwavelength photoacoustic imaging in vivo†
Nanoscale ( IF 5.8 ) Pub Date : 2018-08-07 00:00:00 , DOI: 10.1039/c8nr03973a
Ji Hun Park _{1,

2,

3,

4} , Diego S. Dumani _{2,

3,

4,

5,

6} , Ammar Arsiwala _{1,

2,

3,

4} , Stanislav Emelianov _{2,

3,

4,

5,

6} , Ravi S. Kane _{1,

2,

3,

4}

Affiliation

Photoacoustic imaging using exogenous contrast agents has emerged as a hybrid technique that enables the deep imaging of optical properties of tissues with high spatial resolution. The power of this imaging technique can be greatly enhanced by the use of contrast agents that absorb at near-infrared wavelengths and whose optical properties can be modulated in response to the local environment. We have designed contrast agents consisting of gold nanoparticles coated with anisotropic silica nanoshells. The tunable aggregation of these janus particles in cell culture media resulted in a dramatic amplification of photoacoustic signals in the near-infrared region. We also demonstrated imaging using these contrast agents in mammalian cells, including macrophages and breast cancer cells as well as in vivo. The ability to modulate janus particle aggregation in response to a range of stimuli in combination with the high resolution and deep penetration of multiwavelength photoacoustic imaging are attractive for a broad range of applications in diagnostic imaging and theranostics.

中文翻译：

金-二氧化硅janus纳米粒子的可调谐聚集，可在体内进行对比增强的多波长光声成像†

使用外源性造影剂的光声成像已成为一种混合技术，能够以高空间分辨率对组织的光学特性进行深度成像。通过使用在近红外波长处吸收并且可以响应于局部环境而调节其光学特性的造影剂，可以大大增强该成像技术的功能。我们设计了造影剂，该造影剂由涂有各向异性二氧化硅纳米壳的金纳米颗粒组成。这些janus颗粒在细胞培养基中的可调谐聚集导致近红外区域中光声信号的急剧放大。我们还证明了使用这些造影剂在哺乳动物细胞（包括巨噬细胞和乳腺癌细胞）以及体内成像。响应一系列刺激而调节剑齿颗粒聚集的能力，以及多波长光声成像的高分辨率和深度穿透，对于诊断成像和治疗诊断学的广泛应用具有吸引力。

更新日期：2018-08-07

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