Gold nanoparticles (AuNPs)-embedded paper was coupled with ion-transmission mass spectrometry (MS) to enable the highly sensitive detection of chemical warfare agent (CWA) simulants in solutions. With the assistance of a low-temperature plasma (LTP) probe, we found that AuNPs were capable to enhance the ionization efficiencies of target analytes, with MS signal intensities surprisingly undergone an 800-fold increase under optimized conditions. The interaction between AuNPs and the radiofrequency electromagnetic field was believed to promote the desorption/ionization process, resulting in the unusual signal enhancement phenomenon. Based on this finding, we established a method for the rapid analysis of two simulants of nerve agents, dimethyl methylphosphonate (DMMP) and diisopropyl methylphosphonate (DIMP), with a dynamic range from 0.5 ng/mL to 100 ng/mL and detection limits of 0.1 ng/mL and 0.3 ng/mL, respectively. As sample pretreatments have been eliminated, the developed strategy is particularly promising for the on-site detection of CWAs considering its simple and rapid analytical workflow.

嵌入金纳米颗粒（AuNPs）的纸张与离子传输质谱（MS）结合使用，可以对溶液中的化学战剂（CWA）模拟物进行高灵敏度检测。借助低温等离子体（LTP）探针，我们发现AuNPs能够增强目标分析物的电离效率，在优化条件下，MS信号强度出人意料地增加了800倍。认为AuNP与射频电磁场之间的相互作用会促进解吸/电离过程，从而导致异常的信号增强现象。基于此发现，我们建立了一种用于快速分析神经刺激剂的两种模拟物的方法，其动态范围为0，这是甲基膦酸二甲酯（DMMP）和二异丙基甲基膦酸二异丙酯（DIMP）。5 ng / mL至100 ng / mL，检出限分别为0.1 ng / mL和0.3 ng / mL。由于已经取消了样品预处理，考虑到其简单，快速的分析工作流程，这种开发的策略对于现场检测CWA尤其有希望。