Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention,Molecular Nutrition & Food Research

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Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2018-08-29 , DOI: 10.1002/mnfr.201800079
Besma Abbaoui _{1,

2,

3} , Christopher R. Lucas _{3,

4,

5} , Ken M. Riedl _{2,

5} , Steven K. Clinton _{5,

6} , Amir Mortazavi _{5,

6}

Affiliation

Bladder cancer is a significant health burden due to its high prevalence, risk of mortality, morbidity, and high cost of medical care. Epidemiologic evidence suggests that diets rich in cruciferous vegetables, particularly broccoli, are associated with lower bladder cancer risk. Phytochemicals in cruciferous vegetables, such as glucosinolates, which are enzymatically hydrolyzed to bioactive isothiocyanates, are possible mediators of an anticancer effect. In vitro studies have shown inhibition of bladder cancer cell lines, cell cycle arrest, and induction of apoptosis by these isothiocyanates, in particular sulforaphane and erucin. Although not yet completely understood, many mechanisms of anticancer activity at the steps of cancer initiation, promotion, and progression have been attributed to these isothiocyanates. They target multiple pathways including the adaptive stress response, phase I/II enzyme modulation, pro‐growth, pro‐survival, pro‐inflammatory signaling, angiogenesis, and even epigenetic modulation. Multiple in vivo studies have shown the bioavailability of isothiocyanates and their antitumoral effects. Although human studies are limited, they support oral bioavailability with reasonable plasma and urine concentrations achieved. Overall, both cell and animal studies support a potential role for isothiocyanates in bladder cancer prevention and treatment. Future studies are necessary to examine clinically relevant outcomes and define guidelines on ameliorating the bladder cancer burden.

中文翻译：

十字花科蔬菜，异硫氰酸盐和膀胱癌的预防

膀胱癌由于其高患病率，死亡风险，发病率和高昂的医疗费用而成为重要的健康负担。流行病学证据表明，富含十字花科蔬菜，尤其是西兰花的饮食与降低膀胱癌的风险有关。十字花科蔬菜中的植物化学物质（如芥子油苷）被酶水解为生物活性异硫氰酸盐，可能是抗癌作用的介质。体外研究表明，这些异硫氰酸酯（尤其是萝卜硫烷和芥酸）可抑制膀胱癌细胞系，抑制细胞周期并诱导凋亡。尽管尚未完全了解，但在癌症发生，发展和进展的步骤中，许多抗癌活性机制都归因于这些异硫氰酸酯。它们靶向多种途径，包括适应性应激反应，I / II期酶调节，促生长，促生存，促炎信号传导，血管生成，甚至表观遗传调节。多项体内研究表明异硫氰酸酯的生物利用度及其抗肿瘤作用。尽管人体研究有限，但它们支持口服生物利用度，并达到了合理的血浆和尿液浓度。总体而言，细胞和动物研究均支持异硫氰酸盐在膀胱癌预防和治疗中的潜在作用。未来的研究对于检查临床相关结局和确定减轻膀胱癌负担的指导方针是必要的。甚至表观遗传的调制。多项体内研究表明异硫氰酸酯的生物利用度及其抗肿瘤作用。尽管人体研究有限，但它们支持口服生物利用度，并达到了合理的血浆和尿液浓度。总体而言，细胞和动物研究均支持异硫氰酸盐在膀胱癌预防和治疗中的潜在作用。未来的研究对于检查临床相关结局和确定减轻膀胱癌负担的指导方针是必要的。甚至表观遗传的调制。多项体内研究表明异硫氰酸酯的生物利用度及其抗肿瘤作用。尽管人体研究有限，但它们支持口服生物利用度，并达到了合理的血浆和尿液浓度。总体而言，细胞和动物研究均支持异硫氰酸盐在膀胱癌预防和治疗中的潜在作用。未来的研究对于检查临床相关结局和确定减轻膀胱癌负担的指导方针是必要的。细胞和动物研究均支持异硫氰酸盐在膀胱癌预防和治疗中的潜在作用。未来的研究对于检查临床相关结局和确定减轻膀胱癌负担的指导方针是必要的。细胞和动物研究均支持异硫氰酸盐在膀胱癌预防和治疗中的潜在作用。未来的研究对于检查临床相关结局和确定减轻膀胱癌负担的指导方针是必要的。

更新日期：2018-08-29

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