In vitro and in vivo studies of a chlorin-based carbon nanocarrier with photodynamic therapy features†,Photochemical & Photobiological Sciences

当前位置： X-MOL 学术 › Photochem. Photobiol. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

In vitro and in vivo studies of a chlorin-based carbon nanocarrier with photodynamic therapy features†
Photochemical & Photobiological Sciences ( IF 2.7 ) Pub Date : 2018-08-06 00:00:00 , DOI: 10.1039/c8pp00287h
Zhan Zhou ₁ , Yuhui Zheng , Cheng Cheng Zhang , Jinwei Gao , Yiping Tang , Qianming Wang

Affiliation

Carbonaceous materials have long been developed to utilize “nano-spaces” and numerous guest species could be encapsulated. A remarkable fluorescence difference has been observed after newly designed pyropheophorbide-a-appended carbon nanohorns were incorporated in a cellular medium and confocal microscopy was employed for the determination of the intracellular localization. Our study supported the role of carbon nanohorns as carriers of photodynamic therapy (PDT) agents and their heating behavior was discussed. We have developed a theranostic platform based on photosensitizer-conjugated carbon nanostructures and this system has been applied in an animal model. In addition, a negligible toxicity of CNH-Pyro was found in body weight experiments and histopathological examination of the major organs.

中文翻译：

具有光动力治疗功能的二氢卟酚基碳纳米载体的体外和体内研究†

碳质材料长期以来一直被开发来利用“纳米空间”，并且可以封装许多客体物种。将新设计的焦脱镁叶绿酸附加碳纳米角掺入细胞培养基中并采用共聚焦显微镜测定细胞内定位后，观察到显着的荧光差异。我们的研究支持碳纳米角作为光动力治疗（PDT）药物载体的作用，并讨论了它们的加热行为。我们开发了一种基于光敏剂共轭碳纳米结构的治疗诊断平台，该系统已应用于动物模型。此外，在体重实验和主要器官的组织病理学检查中发现CNH-Pyro的毒性可以忽略不计。

更新日期：2018-08-06

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11