Two travellers returning from South America were diagnosed with Andes hantavirus infection, the only member of the Hantaviridae family known to be transmitted from person to person. We describe the clinical course and therapeutic and infection control measures. While both patients showed high viral load (VL) and shedding over several months, 1 patient recovered within 1 week from severe respiratory illness that required noninvasive ventilation, whereas the second patient developed severe hantavirus cardiopulmonary syndrome that required extracorporeal membrane oxygenation for 27 days. The clinical course in the latter patient was complicated by severe disseminated intravascular coagulopathy with diffuse hemorrhage that necessitated mass transfusions, as well as by multiple organ failure, including the need for renal replacement therapy. Results of VL in blood, respiratory secretions, and semen for the first 9 months of follow-up are reported. To our knowledge, these are the first cases of Andes hantavirus infection detected in Europe.

中文翻译：

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进口的安第斯山脉汉坦病毒感染导致的汉坦病毒心肺综合征：多学科挑战，两例并文献复习

两个旅行者从南美返回被诊断为安第斯山脉汉坦病毒感染的唯一成员Hantaviridae已知会在人与人之间传播的家庭。我们描述了临床过程以及治疗和感染控制措施。两名患者均显示出高病毒载量（VL）并在数月内脱落，但有1名患者在1周内从需要无创通气的严重呼吸系统疾病中恢复过来，而第二名患者出现了严重的汉坦病毒性心肺综合征，需要进行体外膜氧合27天。后一患者的临床过程因严重弥散性血管内凝血病和弥散性出血（需要大量输血）以及多器官衰竭（包括需要肾脏替代疗法）而变得复杂。据报道，在随访的前9个月中，血液，呼吸道分泌物和精液中VL的结果。据我们所知，