Background

The incidence of cutaneous malignant melanoma (CMM) is on the rise in many parts of the world. However, there is limited knowledge on the epidemiology of CMM in Canada.

Objective

To conduct a comprehensive population-based study of CMM in Canada.

Methods

We examined patient clinical and pathologic characteristics as well as the incidence and mortality trends of CMM in Canada using 3 independent population-based registries.

Results

In total, 72,565 Canadian patients were given CMM diagnoses during 1992-2010; 47.5% were women. Average age at the time of diagnosis was 56.5 years for women and 60.4 years for men. We report a steady increase in CMM incidence and mortality rates in both sexes. The overall incidence rate of CMM in Canada was 12.29 cases/100,000 person-years. We also report important differences in the incidence and mortality rates between Canadian provinces and territories; the highest incidence of this cancer was documented in Nova Scotia and Prince Edward Island.

Limitations

Data on race, clinical disease stage, and Breslow depth of CMM was not available.

Conclusion

This study, for the first time, defines the disease burden of CMM in Canada and highlights important longitudinal, geographic, and spatial differences in the distribution of CMM in this country.

中文翻译：

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加拿大皮肤恶性黑色素瘤的发病率和死亡率趋势：一项基于人群的综合研究

 背景

在世界许多地区，皮肤恶性黑色素瘤（CMM）的发病率呈上升趋势。然而，对加拿大 CMM 流行病学的了解有限。

 客观的

在加拿大进行一项基于人群的 CMM 综合研究。

 方法

我们使用 3 个独立的基于人群的登记中心检查了加拿大患者的临床和病理特征以及 CMM 的发病率和死亡率趋势。

 结果

1992 年至 2010 年间，共有 72,565 名加拿大患者接受了 CMM 诊断； 47.5%是女性。诊断时的平均年龄女性为 56.5 岁，男性为 60.4 岁。我们报告，两性的 CMM 发病率和死亡率都在稳步上升。加拿大CMM的总体发病率为12.29例/10万人年。我们还报告了加拿大各省和地区之间发病率和死亡率的重要差异；据记录，这种癌症的发病率最高的是新斯科舍省和爱德华王子岛。

 局限性

没有关于种族、临床疾病阶段和 CMM Breslow 深度的数据。

 结论

这项研究首次定义了加拿大 CMM 的疾病负担，并强调了该国 CMM 分布的重要纵向、地理和空间差异。