Poly(2-methacryloyloxyethyl phosphorylcholine)-based biodegradable nanogels for controlled drug release,Polymer Chemistry

当前位置： X-MOL 学术 › Polym. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Poly(2-methacryloyloxyethyl phosphorylcholine)-based biodegradable nanogels for controlled drug release
Polymer Chemistry ( IF 4.1 ) Pub Date : 2018-08-06 00:00:00 , DOI: 10.1039/c8py00948a
Ruihong Xie _{1,

2,

3,

4} , Yefei Tian _{5,

6,

7,

8} , Shaojun Peng _{1,

2,

3,

4} , Liren Zhang _{1,

2,

3,

4} , Yongzhi Men _{8,

9,

10,

11} , Wuli Yang _{1,

2,

3,

4}

Affiliation

Stimulus responsive nanogels have great potential in the application of drug delivery. In this work, biodegradable zwitterionic poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) nanogels were fabricated by the reflux precipitation polymerization, which was clean and convenient for the application of drug delivery. The hydrodynamic size of the obtained PMPC nanogels was below 200 nm with a narrow size distribution (polydispersity index below 0.1). Moreover, the nanogels showed excellent protein adsorption resistance and remained stable at high concentrations of salt. Furthermore, the PMPC nanogels exhibited redox-responsive performance, and the degradation rate of the nanogels increased as the concentration of glutathione and the pH value increased. In addition, the nanogels could be fully disrupted into short linear polymers (M_w = 2000 g mol⁻¹) after 24 h degradation. The doxorubicin-loaded nanogels showed low drug leakage under physiological conditions (below 15% in 24 h), while they presented rapid drug release in a reduction environment (above 80% in 24 h). The cell cytotoxicity assays revealed that the blank zwitterionic nanogels were nontoxic to the human lung adenocarcinoma epithelial cells (A549 cells) even at high concentrations (1 mg mL⁻¹), while the DOX-loaded nanogels showed efficient inhibition to the tumor cells.

中文翻译：

基于聚（2-甲基丙烯酰氧基乙基磷酰胆碱）的可生物降解纳米凝胶，用于控制药物释放

刺激响应性纳米凝胶在药物递送的应用中具有巨大潜力。本工作通过回流沉淀聚合法制备了可生物降解的两性离子聚（2-甲基丙烯酰氧基乙基磷酰胆碱）（PMPC）纳米凝胶，其清洁卫生，便于给药。所获得的PMPC纳米凝胶的流体力学尺寸低于200nm，具有窄的尺寸分布（多分散指数低于0.1）。此外，纳米凝胶表现出优异的蛋白质吸附抗性，并在高盐浓度下保持稳定。此外，PMPC纳米凝胶表现出氧化还原响应性能，并且随着谷胱甘肽浓度和pH值的增加，纳米凝胶的降解速率增加。此外，纳米凝胶可被完全破坏成短的线性聚合物（降解24小时后，M _w = 2000 g mol ^-1）。载有阿霉素的纳米凝胶在生理条件下（在24小时内低于15％）显示出低的药物泄漏，而在还原环境中（在24小时内超过80％）则呈现出快速的药物释放。细胞的细胞毒性试验表明，即使在高浓度（1 mg mL ^-1）下，空白的两性离子纳米凝胶对人肺腺癌上皮细胞（A549细胞）也无毒，而载有DOX的纳米凝胶对肿瘤细胞具有有效的抑制作用。

更新日期：2018-08-06

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11