Cell-Like Micromotors,Accounts of Chemical Research

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Cell-Like Micromotors
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2018-08-03 00:00:00 , DOI: 10.1021/acs.accounts.8b00202
Berta Esteban-Fernández de Ávila ₁ , Weiwei Gao ₁ , Emil Karshalev ₁ , Liangfang Zhang ₁ , Joseph Wang ₁

Affiliation

In the past decade, versatile micro- and nanosized machines have emerged as active agents for large-scale detoxification, sensing, microfabrication, and many other promising applications. Micromachines have also been envisioned as the next advancement in dynamic therapy with numerous proof-of-concept studies in drug delivery, microsurgery, and detoxification. However, the practical use of synthetic micromotors in the body requires the development of fully biocompatible designs facilitating micromotor movement in biological fluids of diverse composition and displaying desired functions in specific locations. The combination of the efficient movement of synthetic micromotors with the biological functions of natural cells has resulted in cell-like micromotors with expanded therapeutic and toxin-removing capabilities toward different biological applications. Thus, these biocompatible and biomimetic cell-like micromotors can provide efficient movement in complex biofluids and mimic the functionalities of natural cells.

中文翻译：

像细胞一样的微电机

在过去的十年中，通用的微米级和纳米级机器已经成为用于大规模排毒，传感，微细加工和许多其他有前途应用的活性剂。微型机器也被认为是动态疗法的下一个进步，它在药物输送，显微外科和排毒方面有许多概念验证研究。然而，合成微马达在体内的实际使用需要开发完全生物相容的设计，以促进微马达在各种组成的生物流体中的运动并在特定位置显示所需的功能。合成微马达的有效运动与天然细胞的生物学功能相结合，导致了细胞样微马达具有针对不同生物学应用的扩展的治疗和去除毒素功能。因此，这些生物相容性和仿生细胞样微电机可以在复杂的生物流体中提供有效的运动并模仿天然细胞的功能。

更新日期：2018-08-03

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