With the description of circulating fetal DNA in maternal blood, noninvasive prenatal diagnostics became theoretically possible. As the presence of background maternal DNA interferes with the detection of fetal DNA, analytical methods require genetic markers capable of distinguishing by quantitative or targeted approaches the minor population of DNA molecules of the fetus. Here we evaluate the feasibility of analyzing fetal DNA with novel DIP-STR genetic markers, designed for the investigation of forensic mixed biological evidence.

中文翻译：

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使用为法医 DNA 混合物分辨率设计的标记分析母体血浆中的胎儿 DNA。

随着对母体血液中循环胎儿 DNA 的描述，无创产前诊断在理论上成为可能。由于背景母体 DNA 的存在会干扰胎儿 DNA 的检测，因此分析方法需要能够通过定量或靶向方法区分胎儿 DNA 分子的少数群体的遗传标记。在这里，我们评估了使用新的 DIP-STR 遗传标记分析胎儿 DNA 的可行性，该基因标记旨在调查法医混合生物学证据。