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Light on the Horizon: Current Research and Future Perspectives in Flow Photochemistry
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2018-08-02 00:00:00 , DOI: 10.1021/acs.oprd.8b00213
Fabrizio Politano 1 , Gabriela Oksdath-Mansilla 1
Affiliation  

Synthetic organic photochemistry is a powerful tool for creating both natural products and molecules with high structural complexity in a simple way and under mild conditions. However, because of the challenges in scaling-up, it has been difficult to apply a photochemical reaction in an industrial process. Flow chemistry provides an opportunity for better control over the conditions of the reaction and, additionally, improved reaction selectivity and enhanced reproducibility. Taking into account that significant interest has focused on the use of flow photochemistry as a method for the synthesis of heterocycles and its applications in target-oriented synthesis over the past few years, the aim of this review is to highlight recent efforts to apply flow photochemistry methodology to diverse reactions as a greener and more scalable process for the pharmaceutical and fine chemical industries. Additionally, the review highlights future perspectives in the development of scale-up strategies, combining photochemical reactions in the continuous-flow multistep synthesis of organic molecules, which is of interest for scientists and engineers alike.

中文翻译:

地平线上的光:流动光化学的当前研究和未来展望

合成有机光化学是一种功能强大的工具,可通过简单的方式并在温和的条件下生成具有高结构复杂性的天然产物和分子。然而,由于规模放大方面的挑战,很难在工业过程中应用光化学反应。流动化学提供了更好地控制反应条件的机会,此外,还提供了改进的反应选择性和增强的重现性。考虑到在过去几年中,人们非常关注将流动光化学用作杂环的合成方法及其在面向靶标的合成中的应用,这篇综述的目的是强调最近在将流态光化学方法学应用于各种反应方面的努力,这是制药和精细化工行业的一种绿色环保且可扩展的过程。此外,这篇综述突出了扩大规模策略发展的未来前景,将光化学反应与有机分子的连续流多步合成相结合,这引起了科学家和工程师的兴趣。
更新日期:2018-08-02
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