Delusions in Parkinson’s disease (PD) are thought to be associated with disease progression and cognitive impairment. However, this symptom description is not consistent in the literature and there is a suggestion that different subgroups of psychotic patients occur in PD, which we aimed to clarify. Case reports were identified through a systematic search of databases (PUBMED, EMBASE, PsychInfo). Cases with isolated delusions were compared to those with both delusions and hallucinations. We identified 184 cases of delusions in PD. Delusions were primarily paranoid in nature (83%) and isolated in 50%. Those with isolated delusions had an earlier onset of PD (46 years vs 55 years), higher rates of impulse control disorders (40.2 vs 10.3%), dopamine dysregulation (29.9 vs 11.3%) and lower rates of cognitive impairment (8.0 vs 26.8%). There is unexpected heterogeneity amongst cases of delusional psychosis, that cannot adequately be explained by existing models of PD psychosis.

中文翻译：

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帕金森氏病的妄想：已发表病例的系统评价

帕金森病（PD）的妄想被认为与疾病进展和认知障碍有关。但是，这种症状描述在文献中并不一致，并且有一个建议是，我们旨在澄清PD中会出现精神病患者的不同亚组。通过系统地搜索数据库（PUBMED，EMBASE，PsychInfo）来确定病例报告。将有孤立妄想的病例与既有幻想又有幻觉的病例进行比较。我们确定了184例PD中的妄想症。妄想本质上主要是偏执狂（83％），孤立的占50％。患有妄想症的人的PD发病较早（46岁vs 55岁），冲动控制障碍发生率较高（40.2 vs 10.3％），多巴胺失调（29.9 vs 11.3％）和认知障碍发生率较低（8.0 vs 26.8％） ）。