1, 2-Disubstituted benzimidazoles are drug discovery targets and play an important role in many areas. Herein, non-noble-metal α-MnO₂ prepared using urea as the additive was found to be an efficient catalyst for the synthesis of antiviral 1,2-disubstituted benzimidazoles via one-pot multistep reactions using dimethyl carbonate and air as green solvent and oxidant, respectively. The catalytic system could tolerate 1, 2-diol or alcohols as raw via cascade oxidation/cyclization/alkylation to realize the desired products in moderate to good yields. The catalyst was characterized by ICP-AES, XRD, BET, SEM, TEM and XPS, which indicates that the surface oxygen species seriously affected the catalytic performance. And the leaching of Na/K ions in tunnels of the catalyst caused loss of catalytic activity of retrieved α-MnO₂.

1，2-二取代的苯并咪唑是药物发现的靶标，并且在许多领域都发挥着重要作用。在本文中，非贵金属α-MnO的₂发现使用尿素作为添加剂制备的三氯甲烷是一种有效的催化剂，可通过一锅多步反应分别使用碳酸二甲酯和空气作为绿色溶剂和氧化剂来合成抗病毒的1,2-二取代的苯并咪唑。该催化体系可通过级联氧化/环化/烷基化反应耐受粗制的1，2-二醇或醇类，从而以中等至良好的收率获得所需的产物。通过ICP-AES，XRD，BET，SEM，TEM和XPS对催化剂进行了表征，表明表面氧种类严重影响了催化性能。和Na / K离子在检索到的α-MnO的催化活性的催化剂损失引起的隧道浸出₂。