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ATP-Driven Temporal Control over Structure Switching of Polymeric Micelles
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-08-01 00:00:00 , DOI: 10.1021/acs.biomac.8b00769 Bingyang Dong 1 , Li Liu 1 , Cong Hu 1
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-08-01 00:00:00 , DOI: 10.1021/acs.biomac.8b00769 Bingyang Dong 1 , Li Liu 1 , Cong Hu 1
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An adenosine triphosphate (ATP)-fueled micellar system in the out-of-equilibrium state was constructed based on 4,5-diamino-1,3,5-triazine (DAT)-containing block copolymer. The block copolymer self-assembled into spherical micelles in equilibrium steady state at pH higher than its pKa. The pendant DAT residues in protonated form acted as ATP catchers via hydrogen bonding and electrostatic interactions. Activated by ATP fuel, the polymeric micelles spontaneously disrupted into small aggregates of ATP/polymer hybrid complexes. The consumption of ATP energy via the enzymatic hydrolysis led to dissociation of the complexes and reversible formation of polymeric micelles. A transient self-assembly cycle, in which the assembly underwent autonomous division-fusion motion, was created using ATP fuel and enzyme; the switching of assembly structure was sustained by continuous supply of ATP fuel. This DAT-containing block copolymer have good biocompatibility, and drug-loaded micelles display ATP-responsive release behavior. It is expected that this ATP-fueled supramolecular assembly system will provide a functional platform for biomimic chemistry and therapeutic applications.
中文翻译：
ATP驱动的时间控制聚合物胶束的结构转换。
基于含4,5-二氨基-1,3,5-三嗪（DAT）的嵌段共聚物，构建了非平衡状态下的三磷酸腺苷（ATP）燃料胶束体系。在高于pH值p K a的平衡稳态下，嵌段共聚物自组装成球形胶束。质子化形式的DAT侧基残基通过氢键和静电相互作用充当ATP捕集剂。聚合物胶束被ATP燃料激活，自发地破裂成ATP /聚合物杂化复合物的小聚集体。通过酶促水解消耗ATP能量导致复合物解离和聚合物胶束的可逆形成。使用ATP燃料和酶创建了一个短暂的自组装循环，在该循环中，组装进行了自主的分裂融合运动。不断供应ATP燃料可维持装配结构的转换。这种含DAT的嵌段共聚物具有良好的生物相容性，载药胶束显示ATP响应释放行为。
更新日期：2018-08-01
中文翻译：
ATP驱动的时间控制聚合物胶束的结构转换。
基于含4,5-二氨基-1,3,5-三嗪（DAT）的嵌段共聚物，构建了非平衡状态下的三磷酸腺苷（ATP）燃料胶束体系。在高于pH值p K a的平衡稳态下，嵌段共聚物自组装成球形胶束。质子化形式的DAT侧基残基通过氢键和静电相互作用充当ATP捕集剂。聚合物胶束被ATP燃料激活，自发地破裂成ATP /聚合物杂化复合物的小聚集体。通过酶促水解消耗ATP能量导致复合物解离和聚合物胶束的可逆形成。使用ATP燃料和酶创建了一个短暂的自组装循环，在该循环中，组装进行了自主的分裂融合运动。不断供应ATP燃料可维持装配结构的转换。这种含DAT的嵌段共聚物具有良好的生物相容性，载药胶束显示ATP响应释放行为。
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