Protoporphyrin IX (PpIX) is an endogenous fluorescent molecule that selectively accumulates in cancer cells treated with the heme precursor 5-aminolevulinic acid (5-ALA). This cancer-specific accumulation of PpIX is used to distinguish tumor from normal tissues in fluorescence-guided surgery (FGS) and to destroy cancer cells by photodynamic therapy (PDT). In this study, we demonstrate that oncogenic Ras/mitogen-activated protein kinase kinase (MEK) pathway can modulate PpIX accumulation in cancer cells.

中文翻译：

---

通过靶向致癌Ras / MEK途径增强癌症特异性原卟啉IX荧光。

原卟啉IX（PpIX）是一种内源性荧光分子，可选择性地蓄积在用血红素前体5-氨基乙酰丙酸（5-ALA）处理的癌细胞中。PpIX的这种癌症特异性积累在荧光引导手术（FGS）中用于区分肿瘤与正常组织，并通过光动力疗法（PDT）破坏癌细胞。在这项研究中，我们证明了致癌性Ras /丝裂原激活的蛋白激酶激酶（MEK）途径可以调节癌细胞中PpIX的积累。