Ten uridine derivatives (lepidiumuridine B-K) were isolated from the seeds of Lepidium apetalum Willd. Lepidiumuridine B-J were previously undescribed compounds, and were structurally characterized using analysis of their NMR and MS data. Lepidiumuridine C, D, I, and J increased cell proliferation and expression of ERα in the MCF-7 cell line. In addition, blockage of ERα completely abolished cell proliferation and expression of ERα in MCF-7 cells, suggesting that the proliferation effects of lepidiumuridine C, D, I, and J were ERα-mediated. The uridine derivatives might belong to undescribed phytoestrogens.

中文翻译：

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来自 Lepidium apetalum Willd 种子的尿苷衍生物。以及它们的雌激素作用

从 Lepidium apetalum Willd 的种子中分离出 10 种尿苷衍生物 (lepidiumuridine BK)。Lepidiumuridine BJ 是以前未描述的化合物，并使用其 NMR 和 MS 数据分析进行结构表征。Lepidiumuridine C、D、I 和 J 增加了 MCF-7 细胞系中的细胞增殖和 ERα 的表达。此外，ERα的阻断完全消除了MCF-7细胞中ERα的细胞增殖和表达，表明lepidiumuridine C、D、I和J的增殖作用是ERα介导的。尿苷衍生物可能属于未描述的植物雌激素。