当前位置: X-MOL 学术Nat. Prod. Rep. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A genomics perspective on natural product biosynthesis in plant pathogenic bacteria.
Natural Product Reports ( IF 10.2 ) Pub Date : 2019-02-20 , DOI: 10.1039/c8np00025e
Florian Baldeweg 1 , Dirk Hoffmeister , Markus Nett
Affiliation  

Covering: up to February 2018 In recent years, genome sequencing revealed the full biosynthetic potential of bacteria causing plant diseases. Bioinformatics and advanced analytical techniques paved the way to clarify the structures of long-sought natural products with a role in virulence. Furthermore, several compounds without disease-associated function were discovered. The exploration of these molecules disclosed persistence strategies of plant pathogenic bacteria outside their hosts and provided access to new bioactive compounds with therapeutic potential. In this review, we will summarize some of the striking findings in the field, paying particular attention to unique natural product pathways and their unprecedented biosynthetic features as well as the biological activities of the retrieved compounds.

中文翻译:

从基因组学角度看植物病原菌中天然产物的生物合成。

覆盖范围:截至2018年2月近年来,基因组测序揭示了引起植物病害的细菌的全部生物合成潜能。生物信息学和先进的分析技术为阐明长期寻求的天然产物的结构铺平了道路,而天然产物具有毒性。此外,发现了几种没有疾病相关功能的化合物。对这些分子的探索揭示了植物病原细菌在其宿主外部的持久性策略,并提供了具有治疗潜力的新生物活性化合物的获取途径。在这篇综述中,我们将总结该领域的一些惊人发现,尤其要注意独特的天然产物途径及其前所未有的生物合成特征以及所回收化合物的生物活性。
更新日期:2018-07-31
down
wechat
bug