Obesity is a widespread health problem that brings about various adipose tissue dysfunctions. The balance of energy storage and energy expenditure is critical for normal fat accumulation and lipid metabolism. Therefore, understanding the molecular basis of adipogenesis and thermogenesis is essential to maintain adipose development and lipid homeostasis. Increasing evidence demonstrated that lncRNAs (long non-coding RNAs), a class of non-protein coding RNAs of >200 nucleotides in length, are identified as key regulators in obesity-related biological processes through diverse regulatory mechanisms. In this review, we concentrate on recent and relevant studies on the roles of lncRNAs in regulation of white adipogenesis, brown adipocyte differentiation and lipid metabolism. In addition, the diagnostic and therapeutic potential of lncRNAs is highlighted, and that will make recommendations for the future application of lncRNAs in the treatment of obesity.

肥胖是广泛的健康问题，其引起各种脂肪组织功能障碍。能量存储和能量消耗之间的平衡对于正常的脂肪积累和脂质代谢至关重要。因此，了解脂肪形成和生热的分子基础对于维持脂肪发育和脂质稳态是必不可少的。越来越多的证据表明，lncRNA（长的非编码RNA）是一类长度大于200个核苷酸的非蛋白质编码RNA，通过多种调控机制被确定为肥胖相关生物过程中的关键调控因子。在这篇综述中，我们集中于lncRNA在调节白色脂肪形成，棕色脂肪细胞分化和脂质代谢中的作用的最新和相关研究。此外，