Intestinal microbial dysbiosis has been described in individuals with an HIV-1 infection and may underlie persistent inflammation in chronic infection, thereby contributing to disease progression. Herein, we induced an HIV-1-like intestinal dysbiosis in rhesus macaques (Macaca mulatta) with vancomycin treatment and assessed the contribution of dysbiosis to SIV disease progression. Dysbiotic and control animals had similar disease progression, indicating that intestinal microbial dysbiosis similar to that observed in individuals with HIV is not sufficient to accelerate untreated lentiviral disease progression.

中文翻译：

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实验性微生物营养不良症不会促进感染SIV的猕猴的疾病进展。

在患有HIV-1感染的个体中，肠道微生物营养不良已被描述，并且可能是慢性感染中持续性炎症的基础，从而促进了疾病的发展。在本文中，我们用万古霉素治疗在恒河猴（猕猴）中诱导了HIV-1样肠道营养不良，并评估了营养不良对SIV疾病进展的贡献。营养不良动物和对照动物的疾病进展相似，表明与在HIV感染者中观察到的相似，肠道微生物失调不足以加速未经治疗的慢病毒疾病的进展。