Intestinal microbial dysbiosis has been described in individuals with an HIV-1 infection and may underlie persistent inflammation in chronic infection, thereby contributing to disease progression. Herein, we induced an HIV-1-like intestinal dysbiosis in rhesus macaques (Macaca mulatta) with vancomycin treatment and assessed the contribution of dysbiosis to SIV disease progression. Dysbiotic and control animals had similar disease progression, indicating that intestinal microbial dysbiosis similar to that observed in individuals with HIV is not sufficient to accelerate untreated lentiviral disease progression.

中文翻译：

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实验性微生物失调不会促进感染 SIV 的猕猴的疾病进展。


HIV-1 感染者的肠道微生物失调已被描述，并且可能是慢性感染中持续炎症的基础，从而导致疾病进展。在此，我们用万古霉素治疗在恒河猴（Macaca mulatta）中诱导了类似 HIV-1 的肠道菌群失调，并评估了菌群失调对 SIV 疾病进展的影响。失调动物和对照动物具有相似的疾病进展，表明与艾滋病毒个体中观察到的肠道微生物失调相似，不足以加速未经治疗的慢病毒疾病进展。