Studies of secondary metabolites (natural products) that cover their isolation, chemical synthesis and bioactivity investigation present myriad opportunities for discovery. For example, the isolation of novel secondary metabolites can inspire advances in chemical synthesis strategies to achieve their practical preparation for biological evaluation. In the process, chemical synthesis can also provide unambiguous structural characterization of the natural products. Although the isolation, chemical synthesis and bioactivity studies of natural products are mutually beneficial, they are often conducted independently. Here, we demonstrate the benefits of a collaborative study of the phomactins, diterpenoid fungal metabolites that serve as antagonists of the platelet activating factor receptor. Our isolation of novel phomactins has spurred the development of a bioinspired, unified approach that achieves the total syntheses of six congeners. We also demonstrate in vitro the beneficial effects of several phomactins in suppressing the rate of repopulation of tumour cells following gamma radiation therapy.

有关次生代谢产物（天然产物）的分离，化学合成和生物活性研究的研究为发现提供了无数机会。例如，新型次生代谢产物的分离可激发化学合成策略的进展，以实现其实用的生物学评估准备。在此过程中，化学合成还可提供天然产物的明确结构特征。尽管天然产物的分离，化学合成和生物活性研究是互利的，但它们通常是独立进行的。在这里，我们证明了作为血小板活化因子受体拮抗剂的Phoactactins，二萜类真菌代谢产物的合作研究的益处。我们分离出新的phoactactins刺激了生物启发的统一方法的发展，该方法可实现六个同类物的总合成。我们还证明了体外抑制多种伽马射线素在伽玛射线治疗后肿瘤细胞再增殖速率方面的有益作用。