Recent reports have revealed the potential of nanostructured materials to display enzyme-like activity for a broad range of applications. In this study, a glycine modified metal–organic framework (MOF) MIL-53(Fe) composite was utilized as an enzyme (e.g. peroxidase) mimic for the generation of reactive oxygen species (ROS) from hydrogen peroxide. The resultant hydroxyl radicals can act as initiators in the presence of chain transfer agents and monomers in aqueous or organic media, allowing for controlled polymerization via reversible addition–fragmentation chain transfer (RAFT). The polymer products present controllable molecular weights, narrow polymer dispersities and high ‘livingness’ as revealed by a chain extension experiment and MALDI-ToF analysis. By continuously supplying hydrogen peroxide to the MOF peroxidase mimic, ultrahigh molecular weight polyacrylamides (M_n > 1 MDa) of low dispersity (Đ < 1.25) were also obtained. By incorporating low cost, highly stable and easily isolated peroxidase-mimicking catalysts, glycine modified MIL-53(Fe) represents a versatile synthetic strategy to produce well-defined polymers from both hydrophilic and hydrophobic monomers.

中文翻译：

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纳米结构酶模拟物促进了受控的RAFT聚合†

最近的报道已经揭示了纳米结构材料在广泛的应用中显示出类似酶的活性的潜力。在这项研究中，甘氨酸修饰的金属-有机骨架（MOF）MIL-53（Fe）复合物被用作模拟过氧化氢产生活性氧（ROS）的酶（例如过氧化物酶）。在水性或有机介质中，在链转移剂和单体存在的情况下，所得羟基自由基可充当引发剂，从而通过可逆加成-断裂链转移（RAFT）。链增长实验和MALDI-ToF分析表明，聚合物产物具有可控制的分子量，较窄的聚合物分散度和较高的“活性”。通过向MOF过氧化物酶模拟物连续供应过氧化氢，还获得了低分散度（Đ <1.25）的超高分子量聚丙烯酰胺（M _n > 1 MDa）。通过结合低成本，高度稳定且易于分离的过氧化物酶模拟催化剂，甘氨酸修饰的MIL-53（Fe）代表了一种通用的合成策略，可以从亲水性和疏水性单体生产出定义明确的聚合物。