N-Acyl-5,5-dimethylhydantoin, a New Mild Acyl-Transfer Reagent in Pd Catalysis: Highly Efficient Synthesis of Functionalized Ketones,Organic Process Research & Development

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N-Acyl-5,5-dimethylhydantoin, a New Mild Acyl-Transfer Reagent in Pd Catalysis: Highly Efficient Synthesis of Functionalized Ketones
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2018-07-30 00:00:00 , DOI: 10.1021/acs.oprd.8b00182
Zhongfeng Luo ₁ , Tingting Liu ₁ , Weijie Guo ₁ , Zijia Wang ₁ , Jingjun Huang _{1,

2} , Yulin Zhu ₁ , Zhuo Zeng _{1,

3}

Affiliation

The palladium-catalyzed Suzuki–Miyaura cross-coupling of N-acyl-5,5-dimethylhydantoins with arylboronic acids has been developed via selective amides C–N bond cleavage. The new reagent is commercially available and air-/moisture-stable, and it offers a variety of ketones in good yields through Suzuki coupling under mild conditions (up to 95%).

中文翻译：

N-酰基-5,5-二甲基乙内酰脲，Pd催化中的一种新型轻度酰基转移试剂：功能化酮的高效合成

N-酰基-5,5-二甲基乙内酰脲与芳基硼酸的钯催化Suzuki-Miyaura交叉偶联是通过选择性酰胺C–N键裂解而开发的。这种新试剂可商购获得，并且对空气/水分稳定，并且在温和的条件下（高达95％）通过Suzuki偶联可提供高产率的多种酮。

更新日期：2018-07-30

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